Proin For Dogs – Medicine for Urinary Incontinence

Urine voiding is controlled by a muscular band of tissue located at the bladder base. This band works like a valve that is controlled consciously by the dog to hold and release urine when needed.

A housetrained a dog is taught to voluntarily control their bladder for timely voiding. Hormones also play a large role in how well a dog is able to control their bladder.

The hormone estrogen in female dogs has an effect on the strength of the muscles that allow urine to escape the bladder. In male dogs, testosterone plays a similar role.

When these hormones are decreased, incontinence becomes an issue. Incontinence is the inability to consciously control the bladder resulting in involuntary leakage of urine.

Does Your Dog Struggle With Incontinence?

Sometimes urinary incontinence is minor without only small quantities of urine escaping and causing a ‘dribble’ of urine here and there. In some cases, urinary incontinence is significantly worse and large amounts of urine escape the bladder.

Urinary incontinence is common in older dogs, where hormone levels have decreased due to age or other health issues. However, older dogs that have been spayed or neutered may have more issues with incontinence – this is due to removal of ovaries or testicles.

It is rare, but urinary incontinence can effect younger dogs as a result of congenital anatomic abnormalities.

How Does Proin Help?

Proin is a drug to help with urinary incontinence and the resulting bladder leakage.

The drug helps by working to tighten the muscles in the bladder that control leakage.

At one time it was a human drug that was marketed for use as a diet drug by the name of Dexatrim. It was pulled from use, however, after the side effects with were deemed too dangerous.

Through various studies,it was shown that the side effect only appeared in humans. As a result, the drug was approved and released for use in dogs with bladder control issues.

It Is Prescription Only

When considering the use of Proin in your dog, you must consult with your vet and make sure that no other issues are present.

For example, if a bladder infection or kidney infection is present, then you must seek an alternative treatment. Make sure your vet is fully aware of all other medications your dog is taking.

  1. Be aware that Proin may help control urinary incontinence, but it has not been shown to cure the issue.
  2. Most dogs that benefit from Proin may need to use the drug for the rest of their lives. In some cases, you may be able to decrease the dosage over time while still remaining effective.
  3. It should never be used alongside MAOIs (examples include Preventic Collar and selegiline), or with epinephrine or ephedrine. It is also possible that it could react with antidepressants, digoxin, aspirin, NSAIDs, and Rimadyl.

Discuss alternative therapies and options with your vet if your dog has diabetes, thyroid or glaucoma issues or high blood pressure. Also be sure to discuss any former allergies to any of the ingredients used in the medication.


Proin is available in several different dosage sizes and is  prescribed based on the weight of the dog needing the medication.

Tablets come in 25 mg, 50 mg, and 75 mg doses and are available in chewable form.  It is also available in the form of oral drops.

Always follow the dosage instructions that are prescribed by your vet. Generally, doses are prescribed at 0.8 mg for every pound and are given every 12 hours with food. Your vet should always be consulted before any decrease or increase in dosage.

If you miss a dose, give the missed dose on the same day as soon as you remember it. However, if you don’t remember until the next day, don’t give an extra dose.

Side Effects From Proin

Some dogs are fortunate to escape with little to no side effects and are able to stay on Proin for extensive amounts of time.

However, other less fortunate dogs may suffer some side effects.

Sometimes side effects are mild and intermittent or short-lived and other times they are drastic and can require that all dosing of the drug be stopped immediately.

Risks and side effects include allergic reactions such as hives and swelling of the face, lips or tongue. Fever and abnormal behaviors like unusual or excessive aggressiveness, restlessness, hyperactivity or irritability could also occur during use.

Should you note that your dog is experiencing an increase in heart rate or blood pressure or has seemed to lose their appetite and refuses to eat, contact your vet

Lastly, another common side effect associated with Proin is lethargy.

Can Diet Help With Urinary Incontinence?

Sometimes a dog’s diet can have a significant effect on urinary incontinence issues.

There are also times when short-term urinary incontinence can be due to the formation of struvite crystals in the urine. This leads to the formation of bladder stones which can develop into a chronic issue if not handled and treatment immediately.

Diets that are high in protein or certain things like ash or mineral content can increase these formations and lead to acute urinary incontinence.

Switching your dog’s food out to a pure, high-quality dog food with low protein content and without mineral and ash can help clear up urinary issues for some dogs.

Hills have a specialist urinary care dog food that is formulated to reduce risk of stones.  Available from Chewy at discount.

Alternatives to Proin

There are various herbs that are used to help strengthen the smooth muscle tissues like those in the urethral sphincter.

These herbs include raspberry leaf, marshmallow, horsetail, yarrow, uva ursi, and plantain.

However, the efficacy of these treatments is debatable.

If you have a female dog, you could try Incurin, a prescription only tablet that will help with estrogen-responsive incontinence.

If the primary cause of the urinary incontinence is hormone imbalance, there are herbs such as oatstraw and wild yam that contain estrogenic compounds for supplementing hormone levels in a female.

Likewise, herbs such as saw palmetto can help to support and stimulate natural hormone production in male dogs with urinary incontinence.

Cranberry is a common treatment for Urinary Tract Infections, and may also help.

Nutrition Strength Urinary Tract Support

This chicken flavored chewable tablet contains 100mg of cranberry extract along with D-mannose.

Discounted at Amazon